The chemokine CX 3 CL 1 promotes trafficking of dendritic cells through 1 inflamed lymphatics
نویسندگان
چکیده
The chemokine CX3CL1 promotes trafficking of dendritic cells through 1 inflamed lymphatics 2 Louise A. Johnson and David G. Jackson 3 Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular 4 Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK 5 Correspondence to: Louise A. Johnson; email: [email protected] 6 Running Title: CX3CL1-dependent lymphatic trafficking 7
منابع مشابه
The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics
Tissue inflammation is characterised by increased trafficking of antigen-loaded dendritic cells (DCs) from the periphery via afferent lymphatics to draining lymph nodes, with a resulting stimulation of ongoing immune responses. Transmigration across lymphatic endothelium constitutes the first step in this process and is known to involve the chemokine CCL21 and its receptor CCR7. However, the pr...
متن کاملGraft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis
PURPOSE The graft site microenvironment has a profound effect on alloimmunity and graft survival. We aimed to study the kinetics and phenotype of trafficking antigen-presenting cells (APC) to the draining lymph nodes (DLNs) in a mouse model of corneal transplantation, and to evaluate the homing mechanisms through which graft site inflammation controls APC trafficking. METHODS Allogeneic donor...
متن کاملThe chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking
PURPOSE Trafficking of corneal antigen-presenting cells (APC) to draining lymph nodes (LN) is critical in triggering immune responses. However, very little is known about the molecular regulation of this pathway. We investigated the expression and function of the chemokine receptor CCR7 in mediating corneal APC migration in inflammation. METHODS Expression of CCR7 and its ligands, CCL21 and C...
متن کاملAn inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
The exit of antigen-presenting cells and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. How such an exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels are unknown. We show that inflammatory cytokines trigger activation of dermal lymphatic endothelial cells (LECs), leading to expressi...
متن کاملCloning and Characterization of a Specific Receptor for the Novel CC Chemokine MIP-3α from Lung Dendritic Cells
Dendritic cells are potent antigen-presenting cells involved in the initiation of immune responses. The trafficking of these cells to tissues and lymph nodes is mediated by members of the chemokine family. Recently, a novel CC chemokine known as MIP-3alpha or liver and activation-regulated chemokine has been identified from the EMBL/GenBank/DDBJ expressed sequence tag database. In the present s...
متن کامل